Main profile

Michał
Pawlak
Research keywords: 
Transcription factor, epigenetics, lipid metabolism, liver fibrosis, inflammation, heart disease, zebrafish, CHD, metabolic disease
Biography: 

September 2015 – September 2018

Project leader under Sonata 8 National Science Centre Programme. “Functional Characterization of Non-Collagenous Extracellular Matrix Proteins as a Potential Molecular Target and Novel Biomarker of Liver Fibrosis”

October 2014 –

Post-doctoral Fellow  at the International Institute of Molecular and Cell Biology, Laboratory of Zebrafish Developmental Genomics: Max Planck/IIMCB Research Group, Warsaw, Poland.

January 2014 - September 2014

Post-doctoral Fellow  at European Genomic Institute for Diabetes, INSERM UMR 1011, Institut Pasteur de Lille, Laboratory of Nuclear Receptors, Cardiovascular Diseases and Diabetes, Lille, France

December 2013

Doctor of Philosophy (Ph.D.) in molecular and cellular biology, Université Lille 2 Droit et Santé, France

October 2009 - December 2013

Ph.D. study at Université Lille Nord de France, INSERM UMR 1011, Institut Pasteur de Lille, Laboratory of Nuclear Receptors, Cardiovascular Diseases and Diabetes - European Genomic Institute for Diabetes, Lille, France

October 2009

Master engineer in Biotechnology, Warsaw University of Life Sciences (Poland)

January 2009 - July 2009

Master project under LLP-Erasmus Student Exchange ProgramGent University, Belgium, Lab Eukaryotic Gene Expression and Signal Transduction, Gent, Belgium

June 2008 - September 2008

Research project in Trinity College DublinMolecular Design Group, School of Immunology and Biochemistry, UREKA Program Science Foundation of Ireland, Dublin, Ireland

Resumé: 

The main goal of my research is the understanding of molecular mechanism of human diseases by using genomic approaches. In my research I had the opportunity to study transcriptional regulation of nuclear receptors coordinating multiple metabolic pathways in physiological condition and pathology by using multiple molecular biology techniques and murine models.

  1. Currently I am studying genomic and epigenomic regulation of heart development by using zebrafish model and next generation sequencing (NGS) techniques to elucidate the molecular mechanism of congenital heart disease (CHD).
  1. My second project is related to cellular and molecular mechanisms of liver damage and regeneration by using again zebrafish model. This study is to identify potential molecular biomarkers of liver damage and search for molecular targets for the treatment of chronic liver disease. We are using a wide range of techniqueas starting from in vivo models of chemically-induced liver damage to NGS-based approaches.

 

Techniques and tools used in our studies:

Next-generation sequencing (NGS) techniques (ChIP-seq, RNA-seq), ATAC-seq, genome editing (CRISPR), genetic models of congenital heart disease (CHD), chemical models of liver damage, transgenic zebrafish lines, FACS, light-sheet microscopy, histology and others.